What medicine can lower insulin? ——Analysis of popular anti-glycemic drugs and hot topics on the entire network in the past 10 days
As the incidence of diabetes increases year by year, how to effectively reduce insulin resistance or supplement insulin has become the focus of public attention. This article combines popular topics on the Internet in the past 10 days to compile a list of scientific anti-glycemic drugs and the latest research progress, and presents them with structured data.
1. Classification and mechanism of action of popular hypoglycemic drugs
| Drug Type | Representative medicine | Mechanism of action | Applicable groups |
|---|---|---|---|
| Biguanidine | Metformin | Inhibit liver glycogenolysis and improve insulin sensitivity | First choice for type 2 diabetes |
| SGLT-2 Inhibitor | Engaliflozin | Export excess glucose through urine | Patients with cardiovascular disease |
| GLP-1 receptor agonist | Smeglute | Stimulate insulin secretion and inhibit glucagon | Obese patients with diabetes |
| Insulin sensitizer | Pioglitazone | Activation of PPAR-γ receptor improves insulin resistance | Significant insulin resistance |
2. Recent research progress on hot drugs (latest in 2023)
| Drug name | Research Institutions | Core Discovery | Source of data |
|---|---|---|---|
| Tirzepatide | Eli Lilly Pharmaceuticals | Dual agonists reduce HbA1c by 2.5% | NEJM August Research |
| Oral insulin ORMD-0801 | Oramed | Phase III clinical trials show safety up to 98% | Diabetes Care |
| Stem Cell Therapy VC-02 | ViaCyte | 1-year follow-up showed a 35% reduction in insulin dosage | JAMA September issue |
3. The popularity ranking of natural insulin reduction methods
According to the statistics of social platform discussions, the most popular natural sugar-reducing methods in the past 10 days:
| Ranking | method | Related ingredients | Discussion volume (10,000) |
|---|---|---|---|
| 1 | Bitter melon extract | Bitter melon | 28.5 |
| 2 | Cinnamon Supplement | Methyl hydroxychalone polymer | 19.2 |
| 3 | Exercise therapy | HIIT Training | 15.7 |
4. Expert advice
1.Individualized medication principles: Professor Ji Linong of Peking University People's Hospital pointed out that drugs need to be selected based on the patient's islet function, BMI, and complications. If obese patients have priority in treating GLP-1 receptor agonists.
2.Trends of combination medication: The 2023 ADA guidelines recommend the basic combination of "metformin + SGLT2 inhibitors", which can reduce the risk of hypoglycemia by 67% (Data source: Diabetes Journal).
3.Monitoring points: Liver function must be checked regularly when using insulin sensitizers, and urinary ketone levels should be monitored when taking SGLT2 inhibitors.
5. Things to note
• Most of the "natural insulin" health products that have been hotly discussed on the Internet have not been clinically verified
• Novo Nordisk's latest warning: Smeglu islide may increase the risk of thyroid C cell tumors
• State Food and Drug Administration announced in September: Beware of illegal addition of glibenurea by online shopping for anti-glycemic Chinese medicine
The statistics cycle of this article: September 1-10, 2023, covering hot topics on platforms such as Weibo, Zhihu, and Toutiao. Please follow the doctor's advice for specific medication, and it cannot replace professional medical advice.
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